Abstract
BACKGROUND: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP.
METHODS: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors.
RESULTS: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhom*ogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01-2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02-2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%.
CONCLUSION: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.
Original language | English |
---|---|
Pages (from-to) | 54-70 |
Number of pages | 17 |
Journal | European Journal of Internal Medicine |
Volume | 60 |
DOIs | |
Publication status | Published - Feb 2019 |
Keywords
- Community acquired pneumonia
- Oseltamivir
- Viral pneumonia
- Influenza
- Viral swab
- Testing
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GLIMP Study Group (2019). An international perspective on hospitalized patients with viral community-acquired pneumonia. European Journal of Internal Medicine, 60, 54-70. https://doi.org/10.1016/j.ejim.2018.10.020
GLIMP Study Group. / An international perspective on hospitalized patients with viral community-acquired pneumonia. In: European Journal of Internal Medicine. 2019 ; Vol. 60. pp. 54-70.
@article{4802a4b9cca645dd9ee7216f01cd4672,
title = "An international perspective on hospitalized patients with viral community-acquired pneumonia",
abstract = "BACKGROUND: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP.METHODS: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors.RESULTS: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhom*ogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01-2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02-2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%.CONCLUSION: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.",
keywords = "Community acquired pneumonia, Oseltamivir, Viral pneumonia, Influenza, Viral swab, Testing",
author = "{GLIMP Study Group} and Dejan Radovanovic and Giovanni Sotgiu and Mateja Jankovic and Mahesh, {Padukudru Anand} and Marcos, {Pedro Jorge} and Abdalla, {Mohamed I} and {Di Pasquale}, {Marta Francesca} and Andrea Gramegna and Silvia Terraneo and Francesco Blasi and Pierachille Santus and Stefano Aliberti and Reyes, {Luis F} and Restrepo, {Marcos I} and Aruj, {Patricia Karina} and Silvia Attorri and Enrique Barimboim and Caeiro, {Juan Pablo} and Garz{\'o}n, {Mar{\'i}a I} and Cambursano, {Victor Hugo} and Adrian Ceccato and Julio Chertcoff and {Cordon D{\'i}az}, Ariel and {de Vedia}, Lautaro and Ganaha, {Maria Cristina} and Sandra Lambert and Gustavo Lopardo and Luna, {Carlos M} and Malberti, {Alessio Gerardo} and Nora Morcillo and Silvina Tartara and Claudia Pensotti and Betiana Pereyra and Scapellato, {Pablo Gustavo} and Stagnaro, {Juan Pablo} and Sonali Shah and Felix L{\"o}tsch and Florian Thalhammer and Kurt Anseeuw and Francois, {Camille A} and {Van Braeckel}, Eva and Vincent, {Jean Louis} and Djimon, {Marcel Zannou} and {Aranha Nou{\'e}r}, Simone and Peter Chipev and Milena Encheva and Darina Miteva and Diana Petkova and Balkissou, {Adamou Dodo} and {van de Garde}, {E M W}",
note = "Copyright {\textcopyright} 2018 European Federation of Internal Medicine. All rights reserved.",
year = "2019",
month = feb,
doi = "10.1016/j.ejim.2018.10.020",
language = "English",
volume = "60",
pages = "54--70",
journal = "European Journal of Internal Medicine",
issn = "0953-6205",
publisher = "Elsevier",
}
GLIMP Study Group 2019, 'An international perspective on hospitalized patients with viral community-acquired pneumonia', European Journal of Internal Medicine, vol. 60, pp. 54-70. https://doi.org/10.1016/j.ejim.2018.10.020
An international perspective on hospitalized patients with viral community-acquired pneumonia. / GLIMP Study Group.
In: European Journal of Internal Medicine, Vol. 60, 02.2019, p. 54-70.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - An international perspective on hospitalized patients with viral community-acquired pneumonia
AU - GLIMP Study Group
AU - Radovanovic, Dejan
AU - Sotgiu, Giovanni
AU - Jankovic, Mateja
AU - Mahesh, Padukudru Anand
AU - Marcos, Pedro Jorge
AU - Abdalla, Mohamed I
AU - Di Pasquale, Marta Francesca
AU - Gramegna, Andrea
AU - Terraneo, Silvia
AU - Blasi, Francesco
AU - Santus, Pierachille
AU - Aliberti, Stefano
AU - Reyes, Luis F
AU - Restrepo, Marcos I
AU - Aruj, Patricia Karina
AU - Attorri, Silvia
AU - Barimboim, Enrique
AU - Caeiro, Juan Pablo
AU - Garzón, María I
AU - Cambursano, Victor Hugo
AU - Ceccato, Adrian
AU - Chertcoff, Julio
AU - Cordon Díaz, Ariel
AU - de Vedia, Lautaro
AU - Ganaha, Maria Cristina
AU - Lambert, Sandra
AU - Lopardo, Gustavo
AU - Luna, Carlos M
AU - Malberti, Alessio Gerardo
AU - Morcillo, Nora
AU - Tartara, Silvina
AU - Pensotti, Claudia
AU - Pereyra, Betiana
AU - Scapellato, Pablo Gustavo
AU - Stagnaro, Juan Pablo
AU - Shah, Sonali
AU - Lötsch, Felix
AU - Thalhammer, Florian
AU - Anseeuw, Kurt
AU - Francois, Camille A
AU - Van Braeckel, Eva
AU - Vincent, Jean Louis
AU - Djimon, Marcel Zannou
AU - Aranha Nouér, Simone
AU - Chipev, Peter
AU - Encheva, Milena
AU - Miteva, Darina
AU - Petkova, Diana
AU - Balkissou, Adamou Dodo
AU - van de Garde, E M W
N1 - Copyright © 2018 European Federation of Internal Medicine. All rights reserved.
PY - 2019/2
Y1 - 2019/2
N2 - BACKGROUND: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP.METHODS: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors.RESULTS: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhom*ogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01-2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02-2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%.CONCLUSION: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.
AB - BACKGROUND: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP.METHODS: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors.RESULTS: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhom*ogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01-2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02-2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%.CONCLUSION: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.
KW - Community acquired pneumonia
KW - Oseltamivir
KW - Viral pneumonia
KW - Influenza
KW - Viral swab
KW - Testing
U2 - 10.1016/j.ejim.2018.10.020
DO - 10.1016/j.ejim.2018.10.020
M3 - Article
C2 - 30401576
SN - 0953-6205
VL - 60
SP - 54
EP - 70
JO - European Journal of Internal Medicine
JF - European Journal of Internal Medicine
ER -
GLIMP Study Group. An international perspective on hospitalized patients with viral community-acquired pneumonia. European Journal of Internal Medicine. 2019 Feb;60:54-70. doi: 10.1016/j.ejim.2018.10.020